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Abstract Memory impairment during aging is believed to be a consequence of decline in neuronal function and increase in neurodegeneration. Accumulation of oxidative damage and reduction of antioxidant defense system play a key role in organismal aging and functional senescence. In our study, we examined the age-related memory impairment (AMI) in relation to oxidative stress using Drosophila model. We observed a decline in cognitive function in old flies with respect to both short-lived and consolidated forms of olfactory memory. Light and electron microscopy of mushroom bodies revealed a reduction in the number of synapses and discernible architectural defects in mitochondria. An increase in neuronal apoptosis in Kenyon cells was also evident in aged flies. Biochemical investigations revealed a comparable age-associated decrease in the activity of antioxidant enzymes such as catalase and superoxide dismutase as well as the GSH level, accompanied by an increase in the level of lipid peroxidation and generation of reactive oxygen species in the brain. There was no significant difference in the activity level of AChE and BChE enzymes between different age groups while immunohistochemical studies showed a significant decrease in the level of ChAT in 50-day-old flies. RNAi-mediated silencing of cat and sod1 genes caused severe memory impairment in 15-day-old flies, whereas, over-expression of cat gene could partially rescue the memory loss in the old flies. We demonstrated that a Drosophila long-lived strain, possessing enhanced activity of antioxidant enzymes and higher rate of resistance to oxidative stress, shows lower extent of AMI compared to normal lifespan strain. Present study provides evidence for involvement of oxidative stress in AMI in Drosophila.

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Clinical studies are prohibitively expensive for the vast majority of dietary supplement manufacturers, hence they are rarely undertaken. A clinical experiment involving 274 persons was done by the developers of CogniStrong to test the recipe.

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The CogniStrong supplement has so far been determined to have no negative side effects. Some users have reported nausea and indigestion after taking the supplement in doses of three or more capsules. As a result, it’s critical to avoid taking too cognistrong review much!

It contains a variety of plant chemicals, one of which aids with memory repair. The antiparasitic properties of curcumin help to keep brain tissue and the tissues around it healthy.

Vitamins B6 and B2 can aid in the health of a person’s brain. Because they have been linked to cognitive decline and memory loss, these vitamins are critical for good health.

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CogniStrong is a drug that helps the brain heal and helps people remember things by getting rid of impurities or toxins that can kill brain cells. It stimulates the brain’s neurons, boosts memory, and enhances creativity.

Bone health and structural integrity depend on adequate intakes of calcium. One of the body’s essential minerals, it may help prevent cancer, high blood pressure, and diabetes in the long run.

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Overall, I think Cognistong is a good supplement. It definitely makes me feel more focused and concentrated when I am working on tasks. I also like that it does not have any harsh side effects, which is something I look for in supplements.